fentanyl, cyproheptadine. Either will increase toxicity from the other by pharmacodynamic synergism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with anticholinergics might raise risk for urinary retention and/or extreme constipation, which can produce paralytic ileus.
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fentanyl, dimenhydrinate. Either improves toxicity of your other by pharmacodynamic synergism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with anticholinergics may possibly boost risk for urinary retention and/or critical constipation, which can bring about paralytic ileus.
Important: Overdose warning Will not apply more than one patch at a time, Unless of course your health care provider lets you know to. Using a lot more patches than recommended may lead to the deadly overdose.
Voxelotor will increase systemic exposure of delicate CYP3A4 substrates. Stay clear of coadministration with delicate CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction from the delicate CYP3A4 substrate(s) if not able to prevent.
lenacapavir will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
buprenorphine transdermal and fentanyl each enhance sedation. Stay clear of or Use Alternate Drug. fentanyl bill 2024 Restrict use to patients for whom option treatment options are insufficient
If this takes place, take the lozenge from your mouth straight away. Rinse your mouth with water and spit any remaining pieces with the lozenge into a sink or bathroom.
pirtobrutinib will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
You can have showers and go swimming. Check out the patch remains on properly afterwards and dry the region across the patch carefully.
After halting a CYP3A4 inducer, as being the effects with the inducer decline, the fentanyl plasma concentration will maximize which could enhance or prolong equally the therapeutic and adverse effects.
nirmatrelvir/ritonavir will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
oxcarbazepine will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to some decrease in fentanyl plasma concentrations, not enough efficacy or, potentially, improvement of the withdrawal syndrome within a affected individual who may have produced Actual physical dependence to fentanyl.
fentanyl and fentanyl intranasal both equally improve sedation. Avoid or Use Alternate Drug. Restrict use to patients for whom alternative treatment options are insufficient